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I have my Motif keyboard connected to my Mac via USB. It shows up in Audio MIDI Setup, but I’m still not getting MIDI in/out of my sequencer application.

When the Motif is connected via USB, it will show up as a MIDI interface in AMS (Audio MIDI Setup). You still need to add an instrument and connect it to the interface (port 1) for it to show up as an instrument in your sequencing application.