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I can’t use my Digi002 or 003 for iTunes or other application playback in Mac OSX with Pro Tools 10 installed.

In one case, having the 002 or 003 selected in the Audio Devices window of AudioMIDI Setup selected was preventing  Avid CoreAudio Manager from launching.  This stopped the 002/003 from playing iTunes (and web browser sounds) even if the 002/003 was selected in System Preferences > Sound.   Select anything other than Avid/Digidesign hardware in AMS’ “Audio Devices” window.  It is not necessary.

Also, be sure to download and installed the latest Avid firewire audio drivers from www.avid.com