This is an impressive product. It sounds truly great for the money -- better than anything in its class near its price range, and the drivers work great for low-latency performance. The integration with Cubase, in particular, is simply superb, although it can just as easily be used with ProTools 9, for example (although without some of the cool remote control features as of this writing). I've also tested it with Reaper and Sonar without problems.
I mainly use it with Cubase 6 on Windows 7 x64, along with a Steinberg MR816 and the total features with this combination of gear are stunning. I couldn't put together features and sound quality anywhere near that price range as of this writing. And just coming close to this combination a few years ago would have been impossible. I'm very aware of the current crop of digital mixers, but so far nothing still sounds as good at this price point and has such great integration with Steinberg products. But don't let it's Steinberg-advantage detract from your decision if you choose not to use Cubase/Nuendo, and prefer to work in PT, Logic, etc. This is a stellar device regardless of DAW choice... but if you are a Cubase user, you get some nice bonuses. The DAW remote control section works beautifully in Cubase and has been very handy.
Also, after owning the n12 for a while now, I did have one technical issue. I contacted Yamaha and they were quick to respond. I received two phone calls from them to help out. They were helpful, and took the time to answer my questions, even though it turned out that my N12 was no longer under warranty (Ahhhh!)... so I took it upon myself to try to fix it. Crazy idea, but I figured I might was well give it a shot before sending it in to them to get fixed by a certified service center.
So I insanely took the entire thing apart to look for loose wires, or see if I had spilled something that might cause the issue, etc... as I took it apart, I noticed how well designed and well-built it is. Physically, this thing is very solid, in and out. It should last for years. Anyway, after I took it apart, I noticed a loose wire! Somehow it had come loose -- maybe during a recent move I might have jarred it loose! It had survived some rough physical handling, so perhaps that was what happened. So I snapped the cable back in properly, re-assembled the N12, and wow - it worked perfectly again! Totally shocked and happy with the result.
I expect years of continued service from this, and even when this thing has been discontinued, and/or when Yamaha stops supporting the driver, it can still act as a great standalone mixer. All in all, probably one of the best gear purchases I've ever made.
At this point, I'm sold on the Yamaha/Steinberg collaboration, and will be very enthusiastic about future product releases. I'd likely buy the N12's successor in a heartbeat. Although, I'm not sure they could improve on the N12 at this price.