Let me start off by saying that I'm a long time proponent of the Nobels ODR-1. I bought one in the '90's when it showed up at a local music store when I had little money and it happened to be a cheaper alternative to a BOSS or Ibanez. I got lucky. It became my "go-to" foundation pedal. I've seen many waves of ODR through obscene price inflations via resale and several duplications. My favorite was the Wampler Underdog (actually an ODR-S), then the Rockett Chicken Soup and Open Road. Neither actually COMPLETELY harnessed the sound and presence of the ODR perfectly, but they were close and much better built than the Nobels. I really enjoyed the Open Road, but the low mid or bass was more exaggerated than the ODR. So, I was excited about the VS-XO with the bass cut on the Open Road and all the diode clipping and bass cut options on the 808 side.
Unfortunately, on the Drive-2 (Left or Open Road-ish side) VS or Truetone accented an odd low midrange set of frequencies differently than the Open Road, and it cannot be dialed out. It's cool in a way. It seems to make every amp sound like a 1x10" combo. So, for some people this might be the key to a good solo tone. On the other side I've never bonded with the majority of TS variants, and this is no exception. Maybe a KOT, but I still wanted more sparkle than that gave me. Drive-1 (right side highly modified TS) has a nice clean boost capability, but I found I liked it almost 100% clean. So, it made more sense to use a more EQ flexible booster instead. The amount of volume on Drive-2 is incredibly high. That also might be good for those looking to pound the front end of an amp.
For reference I play dumbed down or intricate indie pop/rock. My preferred boosts are [the original] Nobels ODR-1, Paul C Timmy, Rockett Blue Note, Barber Gain Changer, and EQD Tone Job (I know it's just a volume booster, but it's awesome!). Some sort of compression gets in there sometimes, too. High gain solos draw on a Fuzz Face, Soul Bender, Brassmaster or Octavia style fuzz or multiple stacked pedals into a modified Tweed Deluxe or Plexi style amp. With the VS-XO was hoping to replace a couple of other pedals with a better build, smaller form factor, and more tonal possibilities.
Bottom line is maybe for a session player that needs the low mids and a TS upper mid boost the VS-XO could be the perfect pedal. It's small, flexible, well built, sounds good, but it's not for me and [unfortunately] won't replace any of the aforementioned pedals.