Avid has announced that they have certified Pro Tools 12 version 12.6 and above as compatible with macOS 10.12.0 (Sierra).
Be sure that your Mac, running macOS 10.12.0 (Sierra), meets the following minimum requirements or higher:
- Intel Core i5 processor
- 8GB RAM (16GB or more recommended)
- Internet connection for installation
- 15GB disk space for installation
- USB-port for iLok 2 authorization
- USB-port, FireWire-port or Thunderbolt-port for CoreAudio-supported audio device
- Supports 64-bit AAX plug-ins in Pro Tools